Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.7K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of Periprosthetic Joint Infections: A Multidisciplinary Approach.

Antibiotics (Basel, Switzerland)·2026
Same author

Global Integration of Regenerative Orthopaedic Education: Curriculum Innovations and Cross-Cultural Challenges.

Indian journal of orthopaedics·2026
Same author

From Volume to Mastery: Reimagining Orthopaedic Residency Training in India.

Indian journal of orthopaedics·2026
Same author

Chondrogenesis of Peripheral Blood-Derived Mesenchymal Stromal Cells.

Cells·2026
Same author

Synovial chondromatosis of the peroneal tendon sheath presenting as a painless ankle swelling: Diagnostic challenge with atypical radiographic findings.

BMJ case reports·2026
Same author

Prevalence and Impact of Musculoskeletal Occupational Injuries among Orthopedic Surgeons: A Cross-Sectional Study.

Indian journal of orthopaedics·2025

Related Experiment Video

Updated: Jan 8, 2026

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris
05:31

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris

Published on: July 28, 2018

16.7K

Microplastics in Musculoskeletal Disorders: An Emerging Threat.

Madhan Jeyaraman1, Naveen Jeyaraman1, Arulkumar Nallakumarasamy2

  • 1Department of Orthopaedics, ACS Medical College, and Hospital, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu 600077 India.

Indian Journal of Orthopaedics
|December 15, 2025
PubMed
Summary
This summary is machine-generated.

Microplastics (MPs) harm the musculoskeletal system by causing inflammation and cellular damage. Research indicates potential long-term bone and muscle degeneration, highlighting the need for human studies on these plastic contaminants.

Keywords:
ApoptosisDegenerationMicroplasticsOsteoclastogenesis

More Related Videos

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis
10:16

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

50.7K
Forming Micro-and Nano-Plastics from Agricultural Plastic Films for Employment in Fundamental Research Studies
08:21

Forming Micro-and Nano-Plastics from Agricultural Plastic Films for Employment in Fundamental Research Studies

Published on: July 27, 2022

4.7K

Related Experiment Videos

Last Updated: Jan 8, 2026

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris
05:31

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris

Published on: July 28, 2018

16.7K
Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis
10:16

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

50.7K
Forming Micro-and Nano-Plastics from Agricultural Plastic Films for Employment in Fundamental Research Studies
08:21

Forming Micro-and Nano-Plastics from Agricultural Plastic Films for Employment in Fundamental Research Studies

Published on: July 27, 2022

4.7K

Area of Science:

  • Environmental Health
  • Toxicology
  • Musculoskeletal Science

Background:

  • Microplastics (MPs) are pervasive environmental contaminants with recognized systemic toxicity.
  • The impact of MPs on the musculoskeletal system remains significantly underexplored.
  • Understanding these effects is crucial given potential widespread human exposure.

Purpose of the Study:

  • To review and synthesize current literature on the effects of microplastics and nanoplastics on the musculoskeletal system.
  • To identify key mechanisms of toxicity and observed outcomes in preclinical and clinical settings.
  • To highlight knowledge gaps and future research directions.

Main Methods:

  • A narrative literature review was performed using major scientific databases (PubMed, Scopus, Web of Science).
  • Studies published between 2010 and 2024 focusing on microplastics, nanoplastics, and their effects on bone, cartilage, and muscle were included.
  • Inclusion criteria prioritized original experimental research, animal models, and available clinical data.

Main Results:

  • Microplastics enter the body through ingestion, inhalation, and dermal absorption, impacting musculoskeletal tissues.
  • Observed effects include oxidative stress, inflammation, apoptosis, disrupted osteoblast/chondrocyte function, increased osteoclastogenesis, and impaired muscle regeneration.
  • Preclinical models show reduced bone density and muscle atrophy following chronic MP exposure; nanoplastics may exhibit different tissue penetration and bioavailability.

Conclusions:

  • Microplastics adversely impact musculoskeletal health via inflammation, oxidative damage, and cellular dysfunction.
  • Current evidence, primarily from preclinical studies, suggests potential for long-term skeletal and muscular degeneration.
  • Urgent need for further clinical investigation to confirm these effects in human populations.