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Updated: Jun 27, 2026

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

Mild Heat Stimulating and Microenvironment Reprogramming Hydrogel for Accelerating Diabetic Wound Healing.

Xueting Xiao^1,2, Yannan Liu^1,2, Dan Li^1,2

¹Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710127, China.

Gels (Basel, Switzerland)

|June 26, 2026

Summary

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This summary is machine-generated.

A novel hydrogel effectively treats diabetic wounds by reprogramming the wound microenvironment and utilizing mild heat stimulation. This innovative approach accelerates wound healing and improves systemic glucose regulation in diabetic rats.

Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing

Background:

Diabetic wounds present complex challenges including hyperglycemia, oxidative stress, inflammation, and poor angiogenesis.
Current treatments for diabetic wounds are often suboptimal, necessitating innovative therapeutic strategies.

Purpose of the Study:

To develop a green synthesized, mild heat-stimulating hydrogel (C-4-N) for reprogramming the diabetic wound microenvironment.
To evaluate the efficacy of the C-4-N hydrogel in promoting diabetic wound healing in a preclinical model.

Main Methods:

Fabrication of C-4-N hydrogel using L-arginine, protocatechuic aldehyde, Compound K, α-lipoic acid-modified chitosan, and 4-arm-PEG-SH.
Investigated synergistic mechanisms including ROS scavenging, glucose regulation, and macrophage polarization modulation.

Keywords:

diabetic wound healing green synthesis microenvironment reprogramming mild photothermal stimulation natural bioactive compounds

Related Experiment Videos

Last Updated: Jun 27, 2026

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

Assessed wound healing in a diabetic rat model with mild photothermal stimulation.

Main Results:

The C-4-N hydrogel demonstrated synergistic reprogramming of the wound microenvironment.
Achieved near-complete wound closure (99.49%) in diabetic rats by day 13 with mild photothermal stimulation.
Showcased enhanced re-epithelialization, collagen deposition, vascular maturation, and improved systemic glucose control.

Conclusions:

The green synthesized C-4-N hydrogel offers a promising therapeutic strategy for chronic diabetic wound management.
Mild photothermal stimulation synergistically enhances the hydrogel's efficacy in promoting wound healing.
This study establishes a novel paradigm for microenvironment reprogramming in diabetic wound care.