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Updated: Jun 27, 2026

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Virtual Agent for Real-Time Motivational Interviewing by Integrating Adaptive Nonverbal Behavior and Language Models
Published on: December 23, 2025
Design, Development, and Evaluation of Multimodal Conversational Agents for Health Data Registration and Monitoring:
Mateus Klein Roman1, Luan Zanatta1, Jeangrei Emanoelli Veiga1
1Institute of Technology, University of Passo Fundo (UPF), Passo Fundo 99052-900, RS, Brazil.
Healthcare (Basel, Switzerland)
|June 26, 2026
Summary
This study introduces a design framework for conversational agents in healthcare, finding both text and voice interfaces acceptable for patient self-monitoring. Further research is needed to assess clinical outcomes.
Area of Science:
- Human-Computer Interaction
- Digital Health
- Conversational AI
Background:
- Patient-generated health data (PGHD) management is crucial for chronic disease self-monitoring.
- Multimodal conversational agents offer a novel approach to engaging patients with eHealth platforms.
- Existing interfaces may not fully leverage the potential of natural language interaction for health data collection.
Purpose of the Study:
- To propose an implementation-oriented design framework for multimodal conversational agents.
- To evaluate the user experience of conversational data-entry workflows in hypertension self-monitoring.
- To compare text-based and voice-based conversational agents against a conventional app interface.
Main Methods:
- Developed a framework operationalizing social intelligence, communication style, anthropomorphic characteristics, and technological mapping.
- Instantiated the framework in two conversational agents integrated into an eHealth platform.
- Conducted a three-arm, single-session feasibility experiment (n=18) comparing app, text, and voice interfaces, using qualitative analysis and the User Experience Questionnaire (UEQ).
Main Results:
- All modalities were acceptable, with positive UEQ scores.
- Conversational agents showed potential for innovation and engagement, with medium to large effect sizes for user experience metrics like Stimulation and Hedonic Quality.
- Voice-based interactions presented minor, session-resolved modality-specific difficulties (e.g., diction).
Conclusions:
- The proposed framework and feasibility study offer preliminary evidence for multimodal conversational interfaces in healthcare.
- The design dimensions align with user feedback, suggesting their relevance for conversational agent development.
- Further adequately powered longitudinal studies are needed to assess clinical and behavioral outcomes.