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Cross-Sectional Mediation Analysis: How Registered Nurses' Knowledge, Attitude, and Practice Influence Adherence to
Regie Buenafe Tumala1, Mousa Yahya Asiri2, Sahar Abdulkareem Alghareeb3
1Medical-Surgical Nursing Department, College of Nursing, King Saud University, Riyadh 12372, Saudi Arabia.
Healthcare (Basel, Switzerland)
|June 26, 2026
Summary
Registered nurses' knowledge, attitude, and practice significantly influence adherence to pressure injury prevention guidelines. Interventions should target these interconnected factors to improve patient safety and reduce pressure injuries.
Area of Science:
- Healthcare Quality and Safety
- Nursing Research
- Patient Care Management
Background:
- Pressure injuries (PIs) are a significant global patient safety issue with high prevalence and mortality.
- The economic impact of PIs is substantial, necessitating improved prevention strategies.
- Inconsistent adherence to pressure injury prevention (PIP) guidelines among registered nurses (RNs) is a critical concern.
Purpose of the Study:
- To investigate the mediating roles of attitude and practice in the relationship between knowledge and adherence to PIP guidelines among RNs.
- To assess RNs' knowledge, attitude, and practice (KAP) concerning PIP guidelines.
- To evaluate the direct relationship between knowledge and adherence, and quantify the mediated pathways.
Main Methods:
- A cross-sectional mediation study involving 166 RNs from Prince Sultan Military Medical City, KSA.
- Data collected using validated instruments for KAP and PIP guideline adherence.
- Statistical analyses included Pearson correlations, multiple linear regression, and parallel mediation analysis with covariates.
Main Results:
- RNs demonstrated low knowledge (29.2%), negative attitude (54.2%), poor practice (32.8%), and low adherence (31.6%) to PIP guidelines.
- Knowledge, attitude, practice, and years of experience were significant predictors of adherence.
- Attitude and practice significantly mediated the relationship between knowledge and adherence, indicating partial mediation.
Conclusions:
- This study highlights that adherence to PIP guidelines is influenced by interconnected cognitive and behavioral factors (KAP).
- The findings underscore the need for integrated interventions to enhance KAP and improve adherence to PIP guidelines.
- Addressing low KAP levels and improving adherence are crucial for effective pressure injury prevention in healthcare settings.
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