Symmetric Surface Acoustic Wave Tweezers Based on 128° YX-LN for Dynamic Manipulation of Particle Patterns

In the fields of cell engineering, bio-fabrication, and targeted therapy, achieving high-precision manipulation of microparticles and cells remains a technical challenge. Although acoustic tweezers based on surface acoustic waves (SAWs) offer a promising solution, the structural complexity of conventional SAW devices has limited their practical applications. This work proposes a symmetric interdigitated transducer (IDT)-based acoustic tweezers device featuring a simple structure and high flexibility for modulating acoustic pressure field patterns and enabling particle manipulation. Theoretical investigations into the particle manipulation mechanism of the proposed device were conducted using the finite element method. A detachable polymethyl methacrylate (PMMA) assembly chamber was also designed. The effectiveness of the device was validated through dynamic and reconfigurable manipulation experiments using fluorescent polystyrene microspheres. Experimental results demonstrate that the proposed device can rapidly and precisely modulate SAW to achieve array-based manipulation of particle clusters, forming corresponding array patterns. Compared with conventional sorting methods, this device offers advantages including low cost, high precision, ease of operation, and good biocompatibility, making it suitable for large-scale manipulation of microparticles and biological cells. This technology has the potential to expand the application landscape of SAW and may emerge as a cutting-edge approach for directed cell assembly and culture.