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Updated: Jun 27, 2026
09:40
A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
Published on: February 6, 2018
Human Sperm Centrosome: From Current Evidence to Future Perspectives-A Systematic Review
Alessandra Parrella1, Llanos Medrano1, Jon Aizpurua2
1IVF Life, Reproductive Medicine, 03540 Alicante, Spain.
Life (Basel, Switzerland)
|June 26, 2026
Summary
The sperm centrosome is vital for early embryonic development. Its integrity and associated proteins are crucial for successful fertilization and preventing embryonic abnormalities.
Area of Science:
- Reproductive biology and developmental science.
- Cell biology and molecular genetics.
Background:
- The sperm centrosome, comprising centrioles and pericentriolar material, is essential for initiating cell division in early embryos.
- It plays a critical role in forming the sperm aster and the first mitotic spindle post-fertilization.
Purpose of the Study:
- To provide an updated overview of the human sperm centrosome.
- To examine its structure, protein composition, and role in reproductive success.
- To investigate its association with embryonic abnormalities.
Main Methods:
- A systematic review of 83 publications.
- Publications reviewed span from 1986 to 2026.
- Focus on structural organization, protein composition, reproductive role, and embryonic abnormalities.
Main Results:
- Key centrosome proteins (centrin, γ-tubulin, pericentrin) are vital for spindle assembly and microtubule nucleation.
- Altered protein expression/localization correlates with poor sperm quality and reduced fertilization.
- Centrosomal dysfunction is linked to fertilization failure, abnormal embryo cleavage, and potential aneuploidy.
Conclusions:
- Sperm centrosomal integrity is clinically relevant for reproductive outcomes.
- Further research is needed for improved diagnostics and targeted therapies.
- Understanding centrosome function is critical for addressing infertility and developmental issues.
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