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Updated: Jun 27, 2026

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

Placenta Accreta Spectrum Risk in Endometriosis: A Retrospective Cohort Study with ART Subanalysis.

Madeline West¹, Amir Alsaidi¹, Michael A Belfort²

¹Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA.

Journal of Clinical Medicine

|June 26, 2026

Summary

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This summary is machine-generated.

Endometriosis increases the risk of placenta accreta spectrum (PAS) disorders and maternal complications. Assisted reproductive technology (ART) further elevates these risks in patients with endometriosis, highlighting the need for specialized care.

Area of Science:

Reproductive Medicine and Obstetrics
Maternal-Fetal Medicine
Gynecologic Oncology

Background:

Endometriosis is a chronic inflammatory condition affecting women of reproductive age.
Previous research suggests potential links between endometriosis and adverse pregnancy outcomes.
The impact of assisted reproductive technology (ART) on these risks in endometriosis patients remains unclear.

Purpose of the Study:

To evaluate the association between endometriosis and the risk of placenta accreta spectrum (PAS) disorders.
To determine if assisted reproductive technology (ART) exacerbates the risk of PAS and other maternal complications in women with endometriosis.
To inform clinical management and patient counseling for high-risk pregnancies.

Main Methods:

Retrospective analysis of multi-institutional data from the TriNetX database.

Keywords:

ART PAS endometriosis outcomes postoperative

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Last Updated: Jun 27, 2026

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

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Inclusion of patients with delivery dates up to December 31, 2024, and prior endometriosis diagnosis.

Propensity score matching to control for confounding variables; calculation of risk ratios for PAS and maternal complications.

Main Results:

Endometriosis significantly increased the risk of PAS disorders (RR 1.74), including accreta, increta, and percreta.
Endometriosis was also associated with higher rates of peripartum hysterectomy, transfusion, postpartum hemorrhage, ICU admission, and sepsis.
Assisted reproductive technology (ART) further elevated risks for PAS disorders, accreta, hysterectomy, transfusion, and postpartum hemorrhage in endometriosis patients.

Conclusions:

Endometriosis is independently associated with an increased risk of placenta accreta spectrum disorders and severe maternal complications.
The use of assisted reproductive technology (ART) in women with endometriosis amplifies these risks.
Comprehensive counseling and a multidisciplinary approach are crucial for managing pregnancies in this high-risk population.