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Updated: Jun 27, 2026

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Intermolecular-Interaction-Driven Adaptive Remodeling: A Network Perspective on Plant Abiotic Stress Responses.

Leidi Liu1,2, Xiangfei Cheng1,2, Yihua Xu1

  • 1Center for Molecular Interactions and Translational Applications, School of Life Sciences, Henan University, Kaifeng 475004, China.

Plants (Basel, Switzerland)
|June 26, 2026
PubMed
Summary

Plant stress adaptation relies on complex intermolecular interactions, not just single genes. This review proposes a framework where dynamic molecular networks remodel plant physiology for survival and productivity under abiotic stress.

Keywords:
abiotic stressabscisic acidadaptive remodelingcalcium signalingchromatin regulationcrop resiliencephosphorylationreactive oxygen speciesredox switchstress memory

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Area of Science:

  • Plant Biology
  • Molecular Biology
  • Stress Physiology

Background:

  • Abiotic stresses (drought, salinity, etc.) disrupt plant homeostasis, affecting growth and productivity.
  • While stress-responsive molecules are known, understanding coordinated adaptation from molecular events to physiological outputs remains a challenge.

Purpose of the Study:

  • To propose an intermolecular interaction-driven adaptive remodeling framework for plant abiotic stress responses.
  • To elucidate how dynamic molecular interactions orchestrate plant survival, recovery, and productivity under stress.

Main Methods:

  • Review of current literature on plant abiotic stress signaling and adaptation.
  • Conceptual framework development integrating molecular events, signaling hubs, and physiological outputs.
  • Emphasis on reactive oxygen species (ROS) and chromatin-associated mechanisms.

Main Results:

  • Stress tolerance emerges from dynamic changes in molecular interactions (receptor-ligand, protein-protein, etc.).
  • Reactive oxygen species (ROS) act as integrative redox switches connecting stress sensing to senescence and recovery.
  • Interaction networks converge on core signaling hubs (ABA, ROS, Ca2+, kinases) to remodel plant traits.

Conclusions:

  • An interaction-centered framework bridges molecular perception and physiological adaptation for climate-resilient agriculture.
  • Natural variation, multi-omics, and genome editing can translate stress biology into crop resilience.
  • Understanding these networks is crucial for developing crops with enhanced abiotic stress tolerance.