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Related Experiment Video

Updated: Jun 27, 2026

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
11:19

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

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Advanced Antibacterial Nanocomposite Fibers for Biomedical Applications.

Francisca Acevedo1,2,3, Manuel Azocar4, Eulàlia Sans-Serramitjana1,3,5

  • 1Millennium Nucleus Bioproducts, Genomics and Environmental Microbiology (BioGEM), Avenida España 1680, Valparaíso 2390123, Chile.

Pharmaceutics
|June 26, 2026
PubMed

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Summary

Ligand-stabilized silver nanoparticles (AgNPs) show enhanced antimicrobial activity and biocompatibility. Incorporating diclofenac-stabilized AgNPs into nanofibers offers a promising solution for challenging wound infections.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Infectious Diseases

Background:

  • Wound infections pose significant clinical challenges due to polymicrobial biofilms and antimicrobial resistance.
  • Conventional treatments are often compromised by these factors.
  • Novel strategies are needed to effectively manage complex wound infections.

Purpose of the Study:

  • To develop and evaluate ligand-stabilized silver nanoparticles (AgNPs) for enhanced antimicrobial activity and cytocompatibility.
  • To investigate the incorporation of these AgNPs into electrospun nanofibers for wound management.
  • To assess the impact of different ligands on AgNP properties and efficacy.

Main Methods:

  • Synthesis of four AgNP formulations stabilized with citrate, cysteine, ketorolac, and diclofenac.
Keywords:
antimicrobial biomaterialsbiofilm-associated infectionselectrospun PCL/PEO compositesligand-stabilized silver nanoparticlesnanoparticle-functionalized nanomaterials

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Last Updated: Jun 27, 2026

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  • Physicochemical characterization (SPR, zeta potential) and antimicrobial assays (MIC, bactericidal).
  • Toxicity (HET-CAM) and cytocompatibility assessments in various cell lines; incorporation into electrospun PCL/PEO nanofibers.

    • Main Results:

    • Diclofenac-stabilized AgNPs (dc-AgNPs) exhibited superior antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans.
    • AgNPs showed high colloidal stability and negligible irritation in HET-CAM assays.
    • Electrospun nanofibers loaded with dc-AgNPs demonstrated significant antimicrobial reductions against tested pathogens.

    Conclusions:

    • Ligand engineering is crucial for optimizing AgNP antimicrobial efficacy and biocompatibility.
    • Dc-AgNPs show potent antimicrobial properties and good safety profiles.
    • The developed dc-AgNP-loaded electrospun nanofibers present a promising advanced wound care technology for biofilm-associated infections.