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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
Astragaloside IV-Loaded Polydopamine/Zeolitic Imidazolate Framework-8 Nanoparticles Embedded in Conductive
Xingjian Liu1, Wei Zhang1, Guanyong Deng1
1School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Pharmaceutics
|June 26, 2026
Summary
This study developed a novel nanocomposite hydrogel to treat chronic wounds. The advanced material promotes healing by managing inflammation, scavenging reactive oxygen species, and providing electrical cues.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing
Background:
- Chronic wounds often stall in the inflammatory phase.
- Excessive reactive oxygen species (ROS) and disrupted electrical signals impede healing.
Purpose of the Study:
- To create a multifunctional nanocomposite hydrogel for advanced wound management.
- To address inflammation, oxidative stress, and electrical cue disruption in wound healing.
Main Methods:
- Fabricated a hydrogel using modified chitosan (PAMB-CMCS) and decellularized extracellular matrix (dECM).
- Incorporated Astragaloside IV-loaded Polydopamine/Zeolitic Imidazolate Framework-8 (AS@PDA/ZIF-8) nanoparticles.
- Utilized amidation condensation reaction for synthesis.
Main Results:
- The hydrogel demonstrated robust mechanical properties (compressive strength: 27.24 kPa, breaking strength: 28.2 kPa) and electrical conductivity (29.84 mS/cm).
- Exhibited significant ROS-scavenging activity and near-infrared (NIR)-responsive photothermal properties (up to 62.55 °C).
- The integrated nanoplatform enhanced antibacterial action and controlled Astragaloside IV release, improving the wound microenvironment.
Conclusions:
- The developed macromolecule-based composite hydrogel presents a promising therapeutic approach for complex wound healing.
- This strategy effectively manages key challenges in refractory wound repair.
