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Related Concept Videos

Other Nuclides: 31P, 19F, 15N NMR01:16

Other Nuclides: 31P, 19F, 15N NMR

Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research.
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a high...
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR01:15

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.
NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...
NMR Spectroscopy: Chemical Shift Overview01:15

NMR Spectroscopy: Chemical Shift Overview

The position of the absorption signal of a sample is reported relative to the position of the signal of tetramethylsilane (TMS), which is added as an internal reference while recording spectra. The difference between the absorption frequencies of the sample and TMS (in Hz) is divided by the spectrometer operating frequency (in MHz) to obtain a dimensionless quantity called the chemical shift. It is reported on the δ (delta) scale and expressed in parts per million.
For instance, the proton...
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...

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Updated: Jun 27, 2026

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
08:55

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

Published on: October 9, 2020

Benchtop High-MAS NMR for Paramagnetic Materials.

Raiker Witter1,2,3,4, Andres Oss1, Radostina Stoyanova5

  • 1Laboratory of Spin Design, Department of Cybernetics, Tallinn University of Technology (TalTech), Ehitajate tee 5, 19086 Tallinn, Estonia.

Molecules (Basel, Switzerland)
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

A new compact solid-state Nuclear Magnetic Resonance (NMR) platform achieves 50 kHz magic-angle spinning (MAS) in a small permanent magnet. This breakthrough enables high-speed MAS for portable and cost-effective NMR applications.

Keywords:
compact NMR instrumentationhigh-speed spinninglow-field NMRmagic-angle spinning (MAS)miniaturized MAS probepermanent magnetportable NMR systemssmall-bore magnet

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Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

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Area of Science:

  • Solid-state Nuclear Magnetic Resonance (NMR) spectroscopy.
  • Materials science and electrochemistry.
  • Compact instrumentation and magnet design.

Background:

  • Traditional NMR often requires large, expensive superconducting magnets.
  • High-speed magic-angle spinning (MAS) is crucial for resolving complex spectra in solid-state NMR.
  • Space and cost constraints limit the accessibility of advanced NMR techniques.

Purpose of the Study:

  • To develop a compact, benchtop solid-state NMR platform capable of high-speed MAS.
  • To demonstrate the feasibility of using a low-field permanent magnet for demanding NMR experiments.
  • To enable portable and cost-effective NMR solutions.

Main Methods:

  • Design and implementation of a novel probe architecture for a 1.4 T permanent magnet.
  • Utilizing miniaturized 1.8 mm rotors for stable high-speed MAS (50 kHz).
  • Employing field-bore orthogonality for efficient magic-angle alignment.

Main Results:

  • Achieved stable 50 kHz MAS in a compact 1.4 T permanent magnet system.
  • Demonstrated the platform's capability with 7Li MAS NMR of paramagnetic LiNi0.5Mn0.5O2.
  • Successfully measured large paramagnetic shifts in a challenging material system.

Conclusions:

  • The developed platform offers a path toward portable, cost-effective high-MAS NMR.
  • Compact permanent-magnet geometries can support advanced solid-state NMR applications.
  • This technology expands the accessibility of high-performance NMR spectroscopy.