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Related Concept Videos

Cross-reactivity00:42

Cross-reactivity

Overview
Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...

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Related Experiment Video

Updated: Jun 27, 2026

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
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Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

Broad Neutralizing Antibodies Against SARS-CoV-2: Current Progress and Engineering Strategies.

Tianrong Jia1,2, Zehong Huang1,2, Ningshao Xia1,2

  • 1State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, School of Life Sciences, Xiamen University, Xiamen 361102, China.

Viruses
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

High-frequency mutations in SARS-CoV-2 challenge vaccine and therapeutic development. This review explores advanced neutralizing antibodies, including nanobodies and AI-optimized formats, to combat viral evolution and enhance antiviral strategies.

Keywords:
SARS-CoV-2antibody cocktailsartificial intelligencebispecific antibodiesbroadly neutralizing antibodiesconserved epitopesnanobodies

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Application of Ha-CoV-2 Pseudovirus for Rapid Quantification of SARS-CoV-2 Variants and Neutralizing Antibodies

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Area of Science:

  • Virology
  • Immunology
  • Biotechnology

Background:

  • SARS-CoV-2 mutations necessitate continuous development of effective vaccines and therapeutics.
  • Neutralizing antibodies are crucial for preventing and controlling viral spread but require adaptation to viral evolution.

Purpose of the Study:

  • To review strategies for developing SARS-CoV-2 neutralizing antibodies with high potency and mutation tolerance.
  • To provide an integrated perspective on various antibody-based approaches for antiviral development.

Main Methods:

  • Review of conventional antibodies targeting distinct S protein epitopes.
  • Exploration of novel antibody formats: nanobodies, antibody cocktails, multi-specific antibodies.
  • Discussion of engineering approaches, including artificial intelligence-enabled optimization.

Main Results:

  • Various antibody-based strategies demonstrate distinct advantages for targeting SARS-CoV-2.
  • Research focuses on achieving both high neutralizing potency and tolerance to viral mutations.
  • AI and novel formats offer promising avenues for enhanced antibody therapies.

Conclusions:

  • Diverse antibody engineering strategies are vital for overcoming SARS-CoV-2 mutations.
  • Continued innovation in antibody formats and optimization is essential for effective antiviral therapies.
  • An integrated view supports the ongoing development of potent and mutation-tolerant neutralizing antibodies.