Related Experiment Video
Updated: Jun 27, 2026
06:24
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Body composition and cardiometabolic changes during gender-affirming hormone therapy: 12-month longitudinal study
Elif Seray Korkmaz1, Ahmet Toygar Kalkan1, Aysen Akalın1
1Department of Endocrinology and Metabolism, Osmangazi University, Eskişehir, Turkey.
Endocrine Research
|June 26, 2026
Summary
Testosterone therapy in transgender men improved body composition over 12 months, with favorable changes in fat mass and fat-free mass. Cardiometabolic indices showed modest shifts, suggesting PAI and TyG may monitor early changes.
Area of Science:
- Endocrinology
- Cardiology
- Transgender Health
Background:
- Testosterone therapy is known to alter body composition in transgender men.
- Short-term cardiometabolic effects of testosterone therapy require further characterization.
Purpose of the Study:
- To evaluate changes in body composition and cardiometabolic parameters over 12 months in transgender men undergoing testosterone therapy.
Main Methods:
- Retrospective observational study of 15 transgender men on intramuscular testosterone therapy.
- Assessment of anthropometrics, body composition, blood pressure, and cardiometabolic markers (lipids, glucose, HbA1c, PAI, TyG index) at baseline and 12 months.
Main Results:
- Significant increases in total testosterone, body weight, BMI, and fat-free mass; significant decrease in body fat percentage.
- Significant decrease in HDL cholesterol; non-significant increase in triglycerides.
- Significant increases in plasma atherogenic index (PAI) and triglyceride-glucose (TyG) index; non-significant changes in blood pressure.
Conclusions:
- Testosterone therapy in transgender men is associated with favorable body composition changes and modest cardiometabolic shifts over 12 months.
- PAI and TyG index may serve as useful indicators for monitoring early cardiometabolic changes.
- Larger prospective studies are needed to validate these findings.
Keywords:
Body compositioncardiometabolic indicesgender-affirming hormone therapytestosterone therapytransgender menMore Related Videos
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