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Updated: Jun 27, 2026

Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing
Published on: August 25, 2018
Research progress on emerging and important Tick-Borne pathogens
Gang Duan1, Linghan Kong2, Sicheng Duan3
1Chongqing Key Laboratory of Highly Pathogenic Microbes, Chongqing Research Center for Disease Prevention and Public Health, Chongqing Center for Disease Control and Prevention, Chongqing Academy of Preventive Medicine, Chongqing, China.
None:
Ticks are important vector arthropods, which can carry and transmit a variety of pathogenic microorganisms, and pose a serious threat to global public health. This study reviews the research progress of the main and emerging tick-borne pathogens, such as Lyme disease related Borrelia, Rickettsia, Babesia, Thrombocytopenia Syndrome Virus (SFTSV), Tick-borne Encephalitis Virus (TBEV), Alongshan virus (ALSV), etc., focuses on their genomic diversity, pathogenicity, transmission and immune escape, co- infection. In addition, the application of new detection technology [Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), metagenomic next-generation sequencing (mNGS), microfluidics] in Tick-Borne pathogens is summarized.It highlights current research limitations, including delayed vaccine development and inadequate surveillance systems. Finally, future research directions are prospected, providing theoretical references for the prevention and control of tick-borne diseases.
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