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Morphologic and functional effects of esophageal cryotherapy.
The Journal of Thoracic and Cardiovascular Surgery
|April 1, 1979
Summary
Cryotherapy applied to the esophagus at -70 to -80°C is safe, causing only temporary changes. Esophageal cryotherapy shows promise for treating local esophageal strictures and webs.
Area of Science:
- Gastroenterology
- Surgical Innovation
- Medical Device Technology
Background:
- Cryotherapy is increasingly used for integumentary disorders.
- Endobronchial cryotherapy is a new treatment for tracheal strictures.
Purpose of the Study:
- To assess the safety and effects of cryotherapy on the esophagus.
- To investigate cryotherapy for esophageal conditions like webs and strictures.
Main Methods:
- 12 cats underwent distal esophageal cryotherapy (-70 to -80°C for 2 minutes).
- Animals were sacrificed at intervals (90 minutes to 42 days) for analysis.
- Esophageal cinefluoroscopy and manometry were performed before sacrifice.
Main Results:
- Cryotherapy was well-tolerated; animals maintained weight and had normal cinefluoroscopy.
- Manometry showed transiently reduced peristalsis, returning to normal quickly.
- Superficial ulceration occurred 4-10 days post-cryotherapy, with complete healing by 28-42 days.
Conclusions:
- Cryotherapy at -70 to -80°C is safe for the esophageal wall.
- Esophageal cryotherapy is a potential treatment for local esophageal webs and strictures.