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Related Experiment Video

Updated: Jun 27, 2026

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics
09:54

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics

Published on: September 10, 2018

pH-Responsive Materials for Therapy and Precision Biomedical Imaging.

Qing Wang1, Zhibin Guo1, Ziqun Chen1

  • 1State Key Laboratory of Advanced Separation Membrane Materials, School of Chemistry & School of Chemical Engineering and Technology & School of Electronics and Information Engineering, Tiangong University, Tianjin 300387, P. R. China.

Chemical & Biomedical Imaging
|June 26, 2026
PubMed
Summary

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This summary is machine-generated.

pH-responsive materials exploit the acidic tumor microenvironment (TME) for targeted therapies and diagnostics. These smart nanomaterials offer controlled drug delivery and enhanced imaging for improved cancer treatment.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Oncology
  • Medical Imaging
  • Drug Delivery

Background:

  • The acidic tumor microenvironment (TME) is a critical pathological feature exploitable for therapeutic and diagnostic strategies.
  • Existing treatments lack specificity, leading to off-target effects and limited efficacy.
  • pH-responsive materials offer a promising avenue for targeted interventions within the TME.

Purpose of the Study:

  • To systematically review the design and application of pH-responsive materials for biomedical imaging and therapy.
  • To highlight the role of these materials in achieving spatial and temporal control over drug delivery and imaging contrast.
  • To discuss the challenges and future directions for clinical translation of pH-responsive nanocarriers.
Keywords:
biomedical imagingnanocarrierspH-responsive materialssmart materialstargeted drug deliverytheranosticstumor microenvironment

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Last Updated: Jun 27, 2026

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Main Methods:

  • Detailed review of fundamental chemical mechanisms of pH responsiveness (dynamic covalent bonds, metal-ligand coordination, noncovalent interactions).
  • Analysis of various nanocarrier platforms incorporating pH-responsive elements (micelles, liposomes, hydrogels, MOFs, PROTACs, peptides).
  • Exploration of applications in advanced imaging modalities and theranostics.

Main Results:

  • pH-responsive materials can be engineered using diverse chemical strategies to respond to acidic TME conditions.
  • Nanocarrier platforms demonstrate structural and functional changes, enabling targeted drug release and enhanced imaging.
  • Applications include activatable probes, theranostics, organelle targeting, and spatiotemporally controlled release systems.

Conclusions:

  • pH-responsive materials significantly enhance diagnostic accuracy, therapeutic specificity, and treatment monitoring capabilities.
  • Clinical translation faces hurdles including synthesis reproducibility, biocompatibility, and in vivo environmental heterogeneity.
  • Future research should focus on AI integration, closed-loop systems, and translational studies to bridge the lab-to-clinic gap.