Mucous membrane pemphigoid with oral involvement: Two cases reports.

Area of Science:

• Oral Medicine
• Dermatology
• Immunology

Background:

• Mucous membrane pemphigoid is a chronic autoimmune bullous disease.
• Oral manifestations are common, often preceding skin lesions.
• Recurrence is frequent, necessitating identification of triggers.

Purpose of the Study:

• To present two case reports of oral mucous membrane pemphigoid.
• To highlight the importance of diagnostic methods in managing this condition.
• To provide insights for dental practitioners regarding early diagnosis and treatment.

Main Methods:

• Clinical and cytological examination of oral lesions.
• Administration of the Oral Health Impact Profile-14 (OHIP-14) questionnaire.
• Histopathological examination and direct immunofluorescence microscopy of biopsied lesions.

Main Results:

• Confirmed diagnosis of mucous membrane pemphigoid in both cases.
• Demonstrated the utility of histopathology and direct immunofluorescence in diagnosis.
• Highlighted the chronic and recurrent nature of the disease.

Conclusions:

• Mucous membrane pemphigoid requires a combination of clinical, cytological, histopathological, and immunofluorescence assessments for accurate diagnosis.
• Meticulous oral hygiene, symptomatic relief, and appropriate medical therapy are key management strategies.
• Early recognition and intervention by dentists can significantly improve patient outcomes and reduce disease flares.