Bioelectrochemical Sensing Dynamics of SARS-CoV-2 Biomarkers

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Infectious Disease Diagnostics

Background:

• The SARS-CoV-2 pandemic highlighted the critical need for efficient diagnostic tools.
• Existing methods face challenges in speed, sensitivity, and accessibility.
• Bioelectrochemical detection offers a promising avenue for rapid diagnostics.

Purpose of the Study:

• To comprehensively review recent advances in bioelectrochemical biosensors for SARS-CoV-2 detection.
• To focus on nucleic acid- and antibody-based strategies.
• To compare different biosensor designs, analytical parameters, and nanomaterial integration.

Main Methods:

• Review of literature on SARS-CoV-2 bioelectrochemical biosensors.
• Analysis of aptasensors, immunosensors, and genosensors.
• Comparison of sensitivity, detection limits, response times, and transduction mechanisms.

Main Results:

• Nucleic acid and antibody-based bioelectrochemical strategies show significant potential for SARS-CoV-2 detection.
• Aptasensors, immunosensors, and genosensors offer diverse approaches with varying advantages and limitations.
• Nanomaterials enhance sensitivity and performance of these biosensors.

Conclusions:

• Bioelectrochemical biosensors are crucial for developing rapid, sensitive, and accessible SARS-CoV-2 diagnostics.
• Further innovation in point-of-care biosensors is essential for future pandemic preparedness.
• Optimized biosensor design and nanomaterial integration are key to improving detection capabilities.