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Updated: Jun 28, 2026

10:53
Ultrasonic Assessment of Myocardial Microstructure
Published on: January 14, 2014
Identifiability limits in ultrasonic microstructure characterisation using attenuation and velocity features:
1Advanced Remanufacturing & Technology Centre (ARTC), Agency for Science, Technology and Research (A*STAR), 3 Cleantech Loop, #01/01 CleanTech Two, 637143, Republic of Singapore.
Ultrasonics
|June 26, 2026
Summary
This study analyzes ultrasound microstructure characterization, finding that parameter coupling and intrinsic variability limit accurate material property recovery. Optimizing observable selection is key for reliable ultrasonic material analysis.
Area of Science:
- Materials Science
- Acoustics
- Signal Processing
Background:
- Ultrasound is increasingly used for microstructure characterization, with performance often evaluated by inversion accuracy.
- The information content within measured ultrasonic responses fundamentally constrains characterization frameworks.
- Identifiability, the ability to uniquely determine microstructural parameters, is crucial for reliable characterization.
Purpose of the Study:
- To directly examine the identifiability of microstructural parameters using ultrasound.
- To analyze the geometry of the forward operator in both canonical and stochastic microstructure models.
- To understand the influence of parameter coupling, dimensional restrictions, and intrinsic variability on characterization accuracy.
Main Methods:
- Analysis of the forward operator's geometry using feature-level ultrasonic observables.
- Sensitivity analysis for a canonical pulse-echo model to identify information limits.
- Investigation of stochastic surrogate microstructures (Gaussian random fields) focusing on attenuation and velocity.
- Application of a variance-weighted Fisher framework to assess parameter recoverability.
Main Results:
- Canonical model analysis revealed information limits due to parameter coupling and dimensional restrictions.
- For stochastic microstructures, the forward map from correlation length and texture coherence to observables was full rank but anisotropic.
- Intrinsic microstructural variability significantly reduced practical identifiability.
- Recoverability depends on the balance between sensitivity magnitude and stochastic variability, not just structural rank.
Conclusions:
- Identifiability limits in feature-level ultrasonic microstructure characterization are primarily governed by forward-map structure and intrinsic variability.
- Single observables yield poorly constrained results, while combined observables improve conditioning.
- This work provides a foundation for developing optimal observable selection strategies for enhanced ultrasonic material characterization.

