Related Experiment Video

Updated: Jun 28, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Genomic Confirmation of HLA-B*15:591 by Next Generation Sequencing

Jarret Merschman1, Derek Benidt1, Justin Kreuter1

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

HLA
|June 26, 2026
PubMed

Abstract:

HLA-B*15:591 is characterised by a single nucleotide substitution in codon 219 in exon 4.

Keywords:
HLA‐B*15:591allele confirmationhistocompatibilityimmunogeneticsnext generation sequencing

More Related Videos

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

Related Experiment Videos

Last Updated: Jun 28, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Articles linked to this work by shared authors, journal, and citation graph.

Characterisation of the Novel HLA-DQA1*01:205N Allele by Next Generation Sequencing and Oxford Nanopore Sequencing.

HLA·2026

Characterisation of the Novel HLA-DRB1*10:52 Allele by Next-Generation Sequencing and Oxford Nanopore Sequencing.

HLA·2026

Genomic Confirmation of HLA-DQA1*01:67:01 by Next Generation Sequencing and Oxford Nanopore Sequencing.

HLA·2026

Genomic Confirmation of HLA-DPA1*01:49 by Next Generation Sequencing and Oxford Nanopore Sequencing.

HLA·2026

Genomic Confirmation of HLA-C*01:155, by Next Generation Sequencing.

HLA·2026

Characterisation of the Novel HLA-A*26:268 Allele by Next Generation Sequencing.

HLA·2026

Description of the Novel HLA-B*18:272 Allele.

HLA·2026

Characterisation of the HLA-DPA1*01:194:01:02 Allele by Next-Generation Sequencing.

HLA·2026

Identification of the Novel HLA-DQB1*06:556 Allele by Next-Generation Sequencing.

HLA·2026

The HLA-A*24:02:190 Allele Identified by Next-Generation Sequencing and Confirmed by Nanopore Sequencing.

HLA·2026

Extended Characterisation of the Coding Sequence of the HLA-C*04:238 Allele by Third-Generation Sequencing.

HLA·2026

Identification of Seven Novel HLA Alleles by Third Generation Sequencing.

HLA·2026

Association of Single-Nucleotide Polymorphisms, rs693 and rs1042031, in the APOB Gene with the Risk of Prostatic Diseases among Lebanese Males.

Asian Pacific journal of cancer prevention : APJCP·2026

Genomic characterization and biological activities of cell-free supernatant from Lactiplantibacillus pentosus CROT01 against clarithromycin-resistant Helicobacter pylori.

Frontiers in cellular and infection microbiology·2026

Single Nucleotide Polymorphisms in Distant Kinship Inference and Forensic Genetic Genealogy.

International journal of molecular sciences·2026

Fatty Acid Metabolism Rewires Glioblastoma Progression and Treg-Mediated Immune Resistance.

Cancers·2026

Scalable high resolution ancestry deconvolution for genomic data.

Nature communications·2026

Interaction of genetic susceptibility and sunlight exposure on primary open-angle glaucoma risk and progression.

The British journal of ophthalmology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us