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OCTA and microperimetry in Behçet's retinal vasculitis: subgroup analysis, structure-function correlation, and
Bruno F A Ferreira1, Alex H Higashi2, Leandro L Prado3
1Department of Ophthalmology, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, 255 Dr. Enéas Carvalho de Aguiar Avenue, Sao Paulo, SP, 05403900, Brazil. brunofortaleza@alumni.usp.br.
International Journal of Retina and Vitreous
|June 26, 2026
Summary
Younger males with Behçet's syndrome (BS) retinal vasculitis show more severe macular changes. Optical coherence tomography angiography (OCTA) and microperimetry reveal structure-function links in inactive disease.
Area of Science:
- Ophthalmology
- Rheumatology
- Medical Imaging
Background:
- Behçet's syndrome (BS) can cause retinal vasculitis, affecting vision.
- Optical coherence tomography angiography (OCTA) and microperimetry assess retinal microvasculature and function.
- Integrated structure-function analysis in inactive BS retinal vasculitis is limited.
Purpose of the Study:
- Evaluate age- and sex-related differences in inactive BS retinal vasculitis.
- Analyze structure-function associations using OCT and OCTA.
- Assess 12-month changes in retinal biomarkers during clinical remission.
Main Methods:
- Observational study of 14 patients (23 eyes) with inactive BS retinal vasculitis.
- 12-month follow-up with OCT, OCTA, and microperimetry to assess retinal thickness, foveal avascular zone (FAZ) area, vascular density (VD), and macular sensitivity (MS).
- Exploratory analyses by sex, age, and OCTA findings; statistical analysis using generalized estimating equations and Spearman's correlation.
Main Results:
- Male sex, younger age (<45 years), and specific OCTA findings correlated with more significant structural and vascular changes.
- Vascular density (VD) showed strong correlations with foveal avascular zone (FAZ) area and retinal thickness.
- Superficial vascular plexus (SVP) VD correlated directly with central macular sensitivity (MS).
Conclusions:
- Younger males with BS retinal vasculitis may experience greater macular involvement.
- Qualitative OCTA findings, especially in the superficial and intermediate plexuses, are linked to structural and functional alterations.
- Preliminary findings require validation in larger, controlled studies due to the exploratory nature and small sample size.
