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Related Concept Videos

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
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Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...

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Related Experiment Video

Updated: Jun 28, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Decoding sarcoidosis chronicity through phenotypic profiling.

Ioannis Tomos1, Georgia Vourli2, Andreas M Matthaiou3

  • 15th Pulmonary Medicine Department, SOTIRIA Chest Diseases Hospital of Athens, Athens 11527, Greece.

Therapeutic Advances in Respiratory Disease
|June 27, 2026
PubMed
Summary
This summary is machine-generated.

This study identified two distinct sarcoidosis phenotypes using cluster analysis. Arthritis presence strongly predicts chronicity, while lymphadenopathy may be protective against chronic sarcoidosis.

Keywords:
chronicityclustering analysisclustersphenotypesprognosissarcoidosis

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

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Last Updated: Jun 28, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Genetics

Background:

  • Sarcoidosis is a granulomatous disease with unpredictable clinical behavior, lacking predictive phenotyping for chronicity.
  • Current clinical practice lacks reliable strategies to identify patients progressing to chronic sarcoidosis.

Purpose of the Study:

  • To identify distinct sarcoidosis phenotypic clusters based on clinical characteristics.
  • To evaluate the predictive value of these clusters for disease outcomes, specifically chronicity.

Main Methods:

  • Retrospective, single-center study of 68 histologically confirmed sarcoidosis patients with >2 years follow-up.
  • Utilized Multiple Correspondence Analysis (MCA) and Hierarchical Clustering on Principal Components (HCPC) for phenotyping.
  • Logistic regression identified prognostic factors for disease chronicity.

Main Results:

  • Two distinct phenotypic clusters were identified: Cluster 1 (minimal extrapulmonary involvement) and Cluster 2 (multi-organ disease).
  • Cluster 2 showed higher frequencies of liver, musculoskeletal, spleen, cardiac, and skin involvement.
  • Arthritis was strongly associated with increased chronicity risk (OR 17.02), while lymph node involvement alone was protective (OR 0.17).

Conclusions:

  • Cluster analysis revealed two distinct sarcoidosis phenotypes.
  • A potential third, arthritis-predominant phenotype emerged in sensitivity analysis.
  • Lone lymphadenopathy (intrathoracic or extrathoracic) appears significantly protective against sarcoidosis chronicity.