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Related Concept Videos

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Pre-mRNA Processing: RNA Splicing01:32

Pre-mRNA Processing: RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...

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Related Experiment Video

Updated: Jun 28, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Transcriptome Reprogramming in Heart Failure: The Hidden Splicing Code.

Francisca Akhigbe1, Ningjing Song1, Jeyashree Alagarsamy2

  • 1Department of Pharmacology, Physiology and Neurobiology, University of Cincinnati, Cincinnati, OH, USA.

Current Cardiology Reports
|June 27, 2026
PubMed
Summary
This summary is machine-generated.

Alternative splicing dysregulation drives heart failure progression. Unique splicing programs in different cardiomyopathies offer potential therapeutic targets for RNA-based heart failure treatments.

Keywords:
Alternative splicingCardiometabolic disorderCardiomyopathyHeart failureTherapeutics

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Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5
10:05

Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5

Published on: November 13, 2015

Related Experiment Videos

Last Updated: Jun 28, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5
10:05

Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5

Published on: November 13, 2015

Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • Genomics

Background:

  • Heart failure is a leading cause of death, characterized by myocardial metabolic, functional, and molecular changes.
  • Cardiomyopathies are diverse disorders triggered by various stressors, leading to significant morbidity and mortality.

Purpose of the Study:

  • To review the molecular mechanisms of heart failure progression, focusing on alternative splicing.
  • To provide an overview of regulatory mechanisms governing cardiac alternative splicing.
  • To highlight disease-specific splicing events in various cardiomyopathies.

Main Methods:

  • Review of current literature on alternative splicing in heart failure.
  • Analysis of regulatory networks controlling splicing outcomes.
  • Examination of disease-specific splicing programs in different cardiomyopathies.

Main Results:

  • Alternative splicing fine-tunes gene function, generating diverse mRNA isoforms.
  • Dysregulated alternative splicing, especially sarcomere gene isoform switching, contributes to cardiovascular diseases.
  • Distinct cardiomyopathies (dilated, ischemic, cardiometabolic) exhibit unique aberrant splicing patterns.

Conclusions:

  • Alternative splicing plays a critical role in cardiac homeostasis and disease.
  • Targeting aberrant splicing presents a promising therapeutic strategy for heart failure.
  • RNA-based approaches offer potential for modulating splicing in heart failure treatment.