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Updated: Jun 29, 2026
11:44
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
Multiomics Reveals NDRG1-Driven Oral Squamous Cell Carcinoma Progression: Competitive Endogenous RNAs Regulation and
Lei Feng1, Yi Ou2, Linqing Tian3
1Yunnan Key Laboratory of Stomatology and Department of Maxillofacial Surgery, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China.
International Dental Journal
|June 27, 2026
Summary
NDRG1 promotes oral squamous cell carcinoma (OSCC) aggressiveness by driving partial epithelial-mesenchymal transition (p-EMT) and altering the tumor microenvironment. This study identifies NDRG1 as a potential diagnostic and therapeutic target for OSCC.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Oral squamous cell carcinoma (OSCC) exhibits high aggressiveness.
- Understanding the molecular mechanisms driving OSCC heterogeneity and its microenvironment is crucial for effective treatment.
Purpose of the Study:
- To elucidate the role of NDRG1 in OSCC evolutionary heterogeneity and spatial microenvironmental remodeling.
- To explore the regulatory axis MSTRG.47889/miR-1299/NDRG1 in OSCC.
Main Methods:
- Integrated analysis of bulk transcriptomics, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics (ST).
- In vivo and in vitro functional assays.
- Identification and validation of the MSTRG.47889/miR-1299/NDRG1 ceRNA regulatory axis.
Main Results:
- The MSTRG.47889/miR-1299/NDRG1 axis promotes OSCC proliferation and invasion while impairing cellular adhesion.
- A NDRG1-high subpopulation drives partial epithelial-mesenchymal transition (p-EMT) and a high glycolytic state.
- NDRG1 is highly expressed in hypoxia-metabolic niches, potentially coordinating with endothelial cells via the ANGPTL4-CDH5 axis to promote a proangiogenic microenvironment.
Conclusions:
- NDRG1 is a pivotal regulator of OSCC progression, driving p-EMT and coordinating niche remodeling.
- NDRG1 represents a potential novel target for OSCC diagnosis and treatment.
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