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Correlation between microRNAs- 604, microRNA-1302- 3p and IL-37 Expression in Iraqi patients with Toxoplasmosis
Zainab Abdul Ammer Hasan1, Hanaa Kamil Hamad1
1Department of Biology, College of Science for Women, University of Baghdad, Iraq.
Iranian Journal of Immunology : IJI
|June 28, 2026
Summary
MicroRNA-604 and microRNA-1302-3p expression is reduced in toxoplasmosis patients, correlating with increased IL-37 levels. These findings suggest potential roles in disease pathogenesis and as biomarkers.
Area of Science:
- Immunology
- Parasitology
- Molecular Biology
Background:
- Toxoplasma gondii causes toxoplasmosis, a globally prevalent parasitic infection.
- MicroRNAs (miRNAs) are epigenetic regulators influencing immune responses, particularly cytokine expression.
Purpose of the Study:
- Investigate serum levels of IL-37 and expression of miR-604 and miR-1302-3p in Iraqi toxoplasmosis patients.
- Evaluate potential correlations and regulatory relationships between these molecules.
Main Methods:
- Study included 100 toxoplasmosis patients and 100 healthy controls.
- Toxoplasmosis diagnosis confirmed by serological tests (TORCH, ELISA).
- Quantitative real-time PCR (RT-qPCR) used to measure miRNA expression in whole blood.
Main Results:
- Significantly reduced expression of miR-604 and miR-1302-3p in patients versus controls.
- Significantly elevated serum IL-37 levels observed in patients compared to controls.
Conclusions:
- Downregulation of miR-604 and miR-1302-3p is associated with increased IL-37 in toxoplasmosis.
- Altered miRNA and IL-37 profiles suggest roles in pathogenesis.
- These molecules may serve as novel diagnostic biomarkers or therapeutic targets for toxoplasmosis.
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