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Related Experiment Video

Updated: Jun 30, 2026

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
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Study protocol for a prospective, cluster randomised control, hybrid type 1 effectiveness-implementation trial to

Hamada H Altalib1,2, Poojith Nuthalapati1,2, Sana F Ali3,4

  • 1Department of Neurology, Yale Comprehensive Epilepsy Center, Yale University School of Medicine, New Haven, Connecticut, USA.

BMJ Neurology Open
|June 29, 2026
PubMed

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Acute and Long-Term EEG and seizure characteristics in new onset refractory status epilepticus (NORSE).

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Accuracy of the rapid-response electroencephalography's Automated Seizure Burden Estimator: A follow-up validation study of version 8 (AccuRASE II).

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Summary

This study developed and tested an electronic health record template for acute seizure action plans to improve epilepsy care. The template aims to reduce patient distress and healthcare use by integrating seizure management into routine visits.

Area of Science:

  • Neurology
  • Health Informatics
  • Quality Improvement

Background:

  • Epilepsy affects 1% of the US population, causing significant burden.
  • Patient education and acute seizure action plans can mitigate adverse outcomes.
  • Electronic health record (EHR) templates can support care but are often perceived as burdensome.

Purpose of the Study:

  • To develop an EHR clinical template embedding an acute seizure action plan into routine neurology visits.
  • To examine the template's effect on epilepsy care quality and healthcare utilization.
  • To identify barriers and facilitators to the template's adoption.

Main Methods:

  • A single-site, prospective, hybrid type 1 effectiveness-implementation study with a sequential mixed-method design.
Keywords:
ANTICONVULSANTSEPILEPSYEVIDENCE-BASED NEUROLOGYHEALTH POLICY & PRACTICEQUALITY OF LIFE

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  • Providers randomized to acute seizure action plan plus general health education or general health education alone.
  • 10 patients per provider enrolled over 12-15 months, followed for 1 year; mixed-methods data collection including interviews and seizure outcome metrics.

    • Main Results:

    • Primary outcome: change in epilepsy quality measure scores between groups post-implementation.
    • Secondary outcomes: changes in individual quality measures, seizure metrics, and healthcare utilization.
    • Implementation assessed using the Unified Theory of Acceptance and Use of Technology and Theoretical Domains Framework.

    Conclusions:

    • The study will provide insights into the effectiveness and implementation of EHR-embedded acute seizure action plans.
    • Findings will inform strategies to improve epilepsy care quality and reduce healthcare burden.
    • Dissemination through peer-reviewed publications and conference presentations is planned.