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One-Pot Tandem Construction of Isoindolinone Derivatives under Visible-Light Photoredox Catalysis
Lifang Qi1, Ying Yu1, Youping Tian1,2
1School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
Abstract:
Inspired by the significance of amide bonds and C3-substituted isoindolinones in chemistry and biology, we successfully developed a visible-light photoredox-catalyzed metal-free tandem one-pot construction of C3-alkylated isoindolinones bearing an amide bond from easily accessible benzohydrazides, 2-carboxybenzaldehydes, and 4-alkyl-1,4-dihydropyridines. This facile synthetic method delivers target compounds with yields ranging from 71% to 90% across various structurally modified substrates and is also applicable to gram-level preparation. The established strategy is conducive to enriching compound candidate libraries, which further meet the research demands for discovering novel biologically active substances.
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