Mathematical Modeling of IOL Power Changes After Pupil Dilation Based on Multifactorial Analysis

This study aimed to explore the factors affecting the changes in intraocular lens (IOL) power after pupil dilation in patients with age-related cataract and to construct linear regression models.

A total of 167 patients with age of 66.47 ± 8.63 (years) were included in this study to evaluate whether pupil dilation led to significant changes in axial length (AL), corneal curvature (K), central anterior chamber depth (ACD), central corneal thickness (CCT), lens thickness (LT), white-to-white corneal diameter (WTW), relative lens position (RLP), and the values of IOL power predicted using different formulas. Pearson linear correlation analysis was performed between dilation-induced IOL power changes (ΔIOL) and other changes in ocular parameters (ΔAL, ΔK, ΔACD, ΔCCT, ΔLT, ΔWTW, and ΔRLP), after which regression models were established using ΔIOL and its correlates.

For each formula, a prediction model of ΔIOL was established using the regression coefficients: ΔIOL_Haigis = 0.06 - 3.381 ΔAL - 1.335 ΔK; ΔIOL_Hoffer-Q = -3.547 ΔAL - 1.318 ΔK; ΔIOL_SRK-T = -3.105 ΔAL - 1.019 ΔK; ΔIOL_Holladay-1 = -3.697 ΔAL - 1.276 ΔK; ΔIOL_Holladay-2 = 0.099 - 3.484 ΔAL - 1.235 ΔK - 0.279 ΔWTW; ΔIOL_Barrett-II = 0.071 - 3.702 ΔAL - 1.147 ΔK + 0.069 ΔWTW.

Multivariate mathematical models of ΔIOL suggest that IOL power changes are mainly related to the changes in AL and K and that the values of ΔAL, ΔK, and ΔWTW can be used to predict ΔIOL that is calculated by various formulas. Trail Registration: Chinese Registry of Clinical Trials: ChiCTR2200056856.