Related Experiment Video

Updated: Jun 30, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Prediction model for early left ventricular systolic dysfunction progression in hypertrophic cardiomyopathy

Yu Li1, Ziqi Duan2, Jinlei Li1

  • 1Department of Emergency Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Cardiovascular Medicine
|June 29, 2026
PubMed

Insights

This study developed a predictive model to assess the risk of early left ventricular systolic dysfunction progression (ELVSDP) in hypertrophic cardiomyopathy (HCM) patients. The model accurately predicts ELVSDP, aiding in early risk stratification and personalized management.

Area of Science:

  • Cardiology
  • Medical Prediction Models
  • Biostatistics

Background:

  • Hypertrophic cardiomyopathy (HCM) patients exhibit heterogeneous risk for early left ventricular systolic dysfunction progression (ELVSDP).
  • Current tools for predicting short- and medium-term ELVSDP in HCM are insufficient.
  • Accurate prediction is crucial for timely intervention and management.

Purpose of the Study:

  • To develop and validate a predictive model for ELVSDP risk in HCM patients.
  • To establish prediction accuracy at 6, 12, and 18 months post-evaluation.
  • To facilitate early risk stratification and individualized patient management.

Main Methods:

  • A cohort of 314 HCM patients without baseline ELVSDP was analyzed.
  • LASSO-Cox regression identified independent predictors of ELVSDP.
  • A nomogram and interactive dynamic prediction tool were constructed and validated.

Main Results:

  • Age, smoking history, BNP levels, and LVOTO were significant predictors of ELVSDP.
  • The predictive model demonstrated high performance (AUC > 0.88, C-index ~0.94).
  • The model showed good calibration and clinical utility, with higher ELVSDP incidence in the high-risk group.

Conclusions:

  • A validated nomogram accurately predicts short-term ELVSDP risk in HCM patients.
  • The model supports early risk stratification and personalized treatment strategies.
  • This tool can improve management of HCM patients at risk for ELVSDP.
Abstract

Keywords:
ELVSDPdisease preventionhypertrophic cardiomyopathynomogramprediction modelrisk identification

More Related Videos

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease08:57

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...