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Hybrid deep feature fusion and ensemble learning for multi-class skin lesion classification
Mahalakshmi G1, Chanthini Baskar2, Sasithradevi A3
1School of Computer Science and Engineering, Vellore Institute of Technology, Chennai, India.
Frontiers in Artificial Intelligence
|June 29, 2026
Summary
This study introduces a Hybrid Bi-Feature Network (HB-Net) for automated skin lesion classification. The HB-Net model effectively combines deep learning features with ensemble classifiers, improving accuracy in challenging dermoscopic datasets.
Area of Science:
- Dermatology
- Computer Science
- Artificial Intelligence
Background:
- Automated skin lesion classification faces challenges like high inter-class similarity, intra-class variance, and extreme class imbalance in dermoscopic datasets.
- Existing deep learning models struggle with these inherent dataset complexities.
Purpose of the Study:
- To propose a novel Hybrid Bi-Feature Network (HB-Net) model for enhanced automated skin lesion classification.
- To overcome limitations of existing methods by integrating deep feature extraction with machine learning classifiers.
Main Methods:
- Fine-tuning DenseNet201 and ResNet50 to extract deep features from dermoscopic images.
- Concatenating global average pooled features and fully connected embeddings, followed by Principal Component Analysis (PCA) and Synthetic Minority Over-sampling Technique (SMOTE).
- Classifying refined features using Support Vector Machines (SVM) and a stacking ensemble classifier (Random Forest and Extreme Gradient Boosting).
Main Results:
- The HB-Net model achieved 0.9049 accuracy, 0.8427 recall, 0.9743 specificity, 0.8594 precision, and 0.8489 F1-score on the HAM10000 dataset.
- Demonstrated superior classification performance compared to separate deep learning models on multi-class skin lesion datasets.
- Validation on the ISIC 2019 dataset confirmed the model's effectiveness.
Conclusions:
- The proposed HB-Net model effectively addresses challenges in skin lesion classification.
- Integrating complementary deep features with ensemble machine learning classifiers is a promising approach for reliable skin lesion diagnosis.
- The hybrid framework offers improved performance for automated skin lesion classification.