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Related Concept Videos

Hydrogen Bonds01:04

Hydrogen Bonds

A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
Hydrogen Bonds00:26

Hydrogen Bonds

Hydrogen BondsHydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.Hydrogen Bonds Control the World!Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are...
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

Dipole Moment of a Molecule
Intermolecular Forces03:13

Intermolecular Forces

Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen bonds, and dispersion...

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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Published on: November 21, 2013

Charge-Assisted Hydrogen-Bonding Enables Quantitative Multicomponent Self-Assembly in Strongly Polar Environments.

Beatriz Torres-Calvo1, Alberto de Juan1,2, Isabel López-Martín1

  • 1Nanostructured Molecular Systems and Materials Group, Organic Chemistry Department, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

ACS Central Science
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a new method for creating stable molecular assemblies using amidinium-carboxylate salt bridges. This approach enables the formation of complex structures even in challenging polar solvents, expanding possibilities in supramolecular chemistry.

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06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Organic Chemistry

Background:

  • Multicomponent discrete assemblies are valuable functional constructs.
  • Assembly relies on cooperativity and directional noncovalent interactions.
  • Many interactions fail in polar solvents, unlike coordination bonds.

Purpose of the Study:

  • Introduce a versatile alternative to existing molecular assembly methods.
  • Demonstrate the formation of stable assemblies in polar environments.
  • Utilize charge-assisted hydrogen bonding and chelate cooperativity.

Main Methods:

  • Employing amidinium-carboxylate salt bridges for molecular assembly.
  • Designing a hexacomponent assembly with tetracarboxylate porphyrins and diamidine linkers.
  • Conducting assembly in DMSO-rich environments.

Main Results:

  • Achieved quantitative formation of a [2+4] hexacomponent assembly.
  • Demonstrated remarkably high kinetic and thermodynamic stability.
  • Validated the effectiveness of amidinium-carboxylate salt bridges in polar solvents.

Conclusions:

  • Amidinium-carboxylate salt bridges offer a robust alternative for molecular assembly.
  • This method enables the creation of stable supramolecular constructs in polar media.
  • The developed [2+4] assembly showcases significant stability and formation efficiency.