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Expression, prognostic value and function of LMBR1L in gastric cancer
Song Liang1, Chaosheng Zhang2, Chuanjun Wang1
1Department of General Surgery, Lu'an Affiliated Hospital of Anhui Medical University, No. 1627, West Wanxi Road, Jin 'an District, Lu'an, 237000, Anhui, China.
Molecular Genetics and Genomics : MGG
|June 29, 2026
Summary
High expression of LMBR1L indicates poor prognosis in gastric cancer patients, suggesting its potential as a prognostic biomarker and therapeutic target for this deadly disease.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Gastric cancer is a major global cause of cancer mortality.
- Effective prognostic biomarkers are crucial for guiding clinical decisions in gastric cancer management.
Purpose of the Study:
- To investigate the role of LMBR1L in gastric cancer.
- To evaluate LMBR1L as a prognostic biomarker for gastric cancer patients.
- To explore LMBR1L as a potential therapeutic target.
Main Methods:
- Immunohistochemistry and Western blot were used to detect LMBR1L protein expression.
- An LMBR1L knockdown cell line and xenograft mouse model were established.
- A nomogram model was constructed incorporating LMBR1L expression and clinical indicators.
Main Results:
- LMBR1L was found to be highly expressed in gastric cancer tissues.
- High LMBR1L expression correlated with lower overall survival (OS) and disease-free survival (DFS) rates.
- LMBR1L was identified as an independent risk factor for gastric cancer prognosis.
- The nomogram model demonstrated good predictive value for patient survival (AUCs ranging from 0.642 to 0.691).
- Knockdown of LMBR1L inhibited gastric cancer growth in vivo.
Conclusions:
- LMBR1L is highly expressed in gastric cancer and associated with poor patient prognosis.
- LMBR1L plays a role in the biological behavior of gastric cancer.
- LMBR1L holds significant value as a prognostic biomarker and potential therapeutic target for gastric cancer.
- This study provides insights into the molecular mechanisms of gastric cancer progression.
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