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Updated: Jun 30, 2026
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Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
Published on: November 30, 2016
Correlations Between the Histologic Growth Patterns of Peritoneal and Liver Metastases From Colorectal Cancer
Noémie Zenaty1, Radu Bachmann2, Charif Khaled1
1Department of Surgical Oncology, Université Libre de Bruxelles (ULB), The Brussels University Hospital (H.U.B), Jules Bordet Institute, Brussels, Belgium.
Annals of Surgical Oncology
|June 29, 2026
Summary
Histologic growth patterns in peritoneal and liver metastases of colorectal cancer are significantly correlated. However, this correlation did not significantly impact patient survival outcomes in this study.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Histologic growth patterns (HGPs) in peritoneal metastasis (PM) and liver metastasis (LM) are prognostic indicators for metastatic colorectal cancer (CRC) patients.
- Understanding the relationship between PMHGP and LMHGP is crucial for refining prognostic models and treatment strategies.
Purpose of the Study:
- To investigate the correlation between peritoneal metastasis histologic growth patterns (PMHGP) and liver metastasis histologic growth patterns (LMHGP) in patients with metastatic colorectal cancer.
- To assess the prognostic significance of different HGP combinations on overall survival (OS) and disease-free survival (DFS).
Main Methods:
- A retrospective bicentric study involving 44 patients who underwent cytoreductive surgery (CRS) and liver metastasis (LM) resection for metastatic CRC.
- Classification of PMHGP as pushing (P-HGP) or infiltrating (I-HGP), and LMHGP as desmoplastic (D-HGP) or non-desmoplastic (ND-HGP).
- Statistical analysis included chi-square test for correlation and Kaplan-Meier/Cox regression for survival analysis.
Main Results:
- A significant correlation was found between PMHGP and LMHGP (p = 0.0085).
- The combination of infiltrating PMHGP and non-desmoplastic LMHGP (I-HGP + ND-HGP) was most frequent (52.3%).
- Patients with I-HGP + ND-HGP showed trends towards shorter OS and DFS, though these did not reach statistical significance.
Conclusions:
- A significant association exists between the histologic growth patterns of peritoneal and liver metastases in colorectal cancer.
- While a correlation was identified, the specific HGP combinations did not demonstrate a statistically significant impact on patient survival in this cohort.
