Lipiodol in embolization therapy: Evolution from a diagnostic to a therapeutic agent

Area of Science:

• Radiology
• Interventional Radiology
• Medical Chemistry

Background:

• Lipiodol (ethiodized oil) was synthesized in 1901 by Marcel Guerbet.
• Initially used as a contrast agent in diagnostic radiology.
• Its application has evolved significantly over the decades.

Purpose of the Study:

• To review the historical development of Lipiodol.
• To discuss the physical properties of ethiodized oil.
• To highlight its current clinical applications in interventional radiology.

Main Methods:

• Literature review of historical data.
• Analysis of physical and chemical properties.
• Compilation of clinical applications in interventional radiology.

Main Results:

• Lipiodol transitioned from a diagnostic contrast medium to a therapeutic agent.
• It is now widely used in embolization procedures.
• Key applications include chemoembolization and embolization of vascular malformations.

Conclusions:

• Ethiodized oil has evolved into a multifunctional agent in interventional radiology.
• Its historical trajectory showcases a significant shift in clinical utility.
• Lipiodol remains a valuable tool in modern interventional procedures.