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Hypochlorous acid testing studies: elective surgeries (Hypoclates:Elective).
Tobias Hoch Al Hessen1,2, Niels Siegel1, Mika P Nadvornik1,3
1Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
BMJ Open
|June 29, 2026
Summary
This study investigates if hypochlorous acid (HOCl) lavage reduces surgical site infections (SSI) in visceral surgery. HOCl lavage is compared to saline to assess its effectiveness in preventing SSIs.
Area of Science:
- Surgical Infection Prevention
- Antimicrobial Agents
- Clinical Trials
Background:
- Surgical site infections (SSI) are a significant burden, with current intraoperative lavage methods lacking proven efficacy.
- Hypochlorous acid (HOCl) shows promise as a biocompatible antimicrobial agent for surgical use.
Purpose of the Study:
- To evaluate the efficacy of standardized intraoperative hypochlorous acid (HOCl) lavage in reducing SSI incidence.
- To compare HOCl lavage against conventional isotonic saline irrigation in elective visceral surgery.
Main Methods:
- A single-centre, prospective, sequential, quasi-experimental trial comparing ~500 patients receiving HOCl lavage with ~500 retrospective controls receiving isotonic saline.
- Primary outcome: SSI incidence (superficial, deep, organ/space) per CDC criteria until hospital discharge or postoperative day 10.
- Secondary outcomes: ICU/hospital length of stay, antibiotic duration, and Comprehensive Complication Index (CCI).
Main Results:
- This section is to be filled once the study is completed and results are available.
Conclusions:
- This section is to be filled once the study is completed and results are available.
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