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Related Concept Videos

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Endoscopic Studies II: Thoracocentesis

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Roles of Electrolytes: Chloride and Bicarbonate

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Updated: Jul 1, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
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Published on: September 24, 2020

Hypochlorous acid testing studies: elective surgeries (Hypoclates:Elective).

Tobias Hoch Al Hessen1,2, Niels Siegel1, Mika P Nadvornik1,3

  • 1Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.

BMJ Open
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

This study investigates if hypochlorous acid (HOCl) lavage reduces surgical site infections (SSI) in visceral surgery. HOCl lavage is compared to saline to assess its effectiveness in preventing SSIs.

Keywords:
Adult surgeryClinical TrialProspective studies

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Area of Science:

  • Surgical Infection Prevention
  • Antimicrobial Agents
  • Clinical Trials

Background:

  • Surgical site infections (SSI) are a significant burden, with current intraoperative lavage methods lacking proven efficacy.
  • Hypochlorous acid (HOCl) shows promise as a biocompatible antimicrobial agent for surgical use.

Purpose of the Study:

  • To evaluate the efficacy of standardized intraoperative hypochlorous acid (HOCl) lavage in reducing SSI incidence.
  • To compare HOCl lavage against conventional isotonic saline irrigation in elective visceral surgery.

Main Methods:

  • A single-centre, prospective, sequential, quasi-experimental trial comparing ~500 patients receiving HOCl lavage with ~500 retrospective controls receiving isotonic saline.
  • Primary outcome: SSI incidence (superficial, deep, organ/space) per CDC criteria until hospital discharge or postoperative day 10.
  • Secondary outcomes: ICU/hospital length of stay, antibiotic duration, and Comprehensive Complication Index (CCI).

Main Results:

  • This section is to be filled once the study is completed and results are available.

Conclusions:

  • This section is to be filled once the study is completed and results are available.