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Updated: Jul 1, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
First Total Synthesis of Cryptolaevilactones, Unique Spiromeroterpenoids
Tomoya Nishida1, Yuta Miura1, Yohei Saito1
1School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan.
None:
Cryptolaevilactones (CLs) A-L (1-12), twelve previously isolated spiromeroterpenoids, feature a unique spiro[3.5]nonene skeleton formed from a polyketide chain and a monoterpene. CLs A-C and L (1-4) are diastereomers with different configurations at three chiral centers around a spiro moiety. Herein, we reported the first total syntheses of 1-3 via a convergent strategy accomplished through the construction of three components, a styryl group, a lactone chain, and a spiro ring moiety (isopropylspiro[3.5]nonenone). In this study, the previously unreported compound 13 (CL N) was identified as a natural product from Cryptocarya laevigata.
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