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Health-Related Quality of Life in Children with Primary Complex Motor Stereotypies
Cade C Mills1,2, Justin Pellicciotti1, E Mark Mahone3
1Johns Hopkins School of Medicine, Department of Neurology, Baltimore, Maryland, USA.
Movement Disorders Clinical Practice
|June 30, 2026
Summary
Children with primary complex motor stereotypies (pCMS) experience lower quality of life, especially in psychosocial areas. Co-occurring ADHD and anxiety significantly impact their health-related quality of life more than stereotypy severity.
Area of Science:
- Pediatric Neurology
- Psychiatry
- Quality of Life Research
Background:
- Primary complex motor stereotypies (pCMS) are movement disorders often accompanied by psychiatric symptoms.
- The impact of pCMS on health-related quality of life (HRQoL) remains understudied.
Purpose of the Study:
- Compare HRQoL in children with pCMS to normative data.
- Evaluate agreement between child and parent HRQoL reports.
- Investigate links between stereotypy severity, psychiatric symptoms, and HRQoL.
Main Methods:
- Cross-sectional study of children (5-17 years) with pCMS.
- Utilized Pediatric Quality of Life Inventory (PedsQL™) for HRQoL assessment.
- Assessed stereotypy severity and co-occurring ADHD, anxiety, and OCD symptoms.
Main Results:
- Children with pCMS reported lower overall and psychosocial HRQoL compared to norms.
- Physical health HRQoL did not significantly differ from normative values.
- ADHD and anxiety symptoms, not stereotypy severity, correlated with reduced HRQoL.
Conclusions:
- Children with pCMS often have diminished psychosocial HRQoL.
- Co-occurring ADHD and anxiety are key factors affecting HRQoL in pCMS.
- Comprehensive assessment of psychosocial and psychiatric status is crucial for managing pCMS.
