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Published on: June 2, 2014
Association of Iron Deficiency Anemia with Migraine: A Case-Control Study
M R N Rahman1, M Saiduzzaman, M S I Bhuya
1Dr Md Rizwa Noor Rahman, Registrar, Department of Neurology, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh;
Mymensingh Medical Journal : MMJ
|June 30, 2026
Summary
Iron deficiency anemia is more prevalent in migraine patients, particularly women. Lower hemoglobin and ferritin levels correlate with migraine severity, suggesting anemia screening and iron supplementation for migraine management.
Area of Science:
- Neurology
- Hematology
- Metabolic Disorders
Background:
- Migraine is a common neurological disorder with complex origins.
- Iron deficiency anemia (IDA) can cause brain metabolic abnormalities and reduced neuronal activity.
Purpose of the Study:
- To investigate the association between iron deficiency anemia and migraine.
- To compare iron levels in migraine patients and healthy individuals.
Main Methods:
- A case-control study involving 155 migraine patients and 155 healthy controls.
- Blood samples analyzed for complete blood count and serum ferritin levels.
- Data collected from November 2019 to April 2021.
Main Results:
- Iron deficiency anemia was significantly more common in migraine patients (p<0.001).
- Migraine patients, especially females, exhibited lower serum hemoglobin and ferritin levels (p<0.001).
- A significant association was found between migraine severity and lower hemoglobin/ferritin levels (p=0.042).
Conclusions:
- An association exists between iron deficiency anemia, hemoglobin, and ferritin levels in migraine patients.
- Investigating IDA in migraine sufferers is recommended.
- Iron supplementation may be a potential therapeutic option for migraine treatment.
