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Related Concept Videos

Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Chronic Inflammation: Introduction

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Related Experiment Video

Updated: Jul 1, 2026

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
07:38

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing

Published on: September 13, 2016

CURE: a phase-based therapeutic framework for chronic inflammation.

Nils Kurzen1, Stefan Weißinger1, Hjalmar Kurzen2,3

  • 1Department of Dermatology and Allergy, LMU Hospital, Munich, Germany.

Frontiers in Immunology
|June 30, 2026
PubMed
Summary

The CURE framework offers a new approach to managing chronic inflammation by controlling immune system dynamics. This phased model aims for durable disease control and relapse prevention in immune-mediated diseases.

Keywords:
classificationhypothesisinflammationskin disease activitytherapy algorithm

Related Experiment Videos

Last Updated: Jul 1, 2026

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
07:38

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing

Published on: September 13, 2016

Area of Science:

  • Systems immunology
  • Nonlinear dynamics
  • Complex systems theory

Background:

  • Chronic inflammation persists in immune-mediated diseases due to self-reinforcing feedback loops and resistance to termination.
  • Unlike acute inflammation, chronic inflammation stabilizes pathologically, driven by cytokine redundancy and immune memory.

Purpose of the Study:

  • Introduce the CURE (CONTROL - UNLOAD and RESET - EQUILIBRATE) framework for phase-based therapeutic management of chronic inflammation.
  • Provide a conceptual model for durable disease control, relapse prevention, and stabilization of functional remission.

Main Methods:

  • The CURE framework is a phase-based therapeutic model integrating systems immunology and nonlinear dynamics.
  • It interprets treatment based on cumulative anti-inflammatory exposure across three phases: CONTROL, UNLOAD and RESET, and EQUILIBRATE.
  • The framework synthesizes mechanistic and clinical evidence from conditions like atopic dermatitis, psoriasis, IBD, and rheumatoid arthritis.

Main Results:

  • Durable disease control depends on therapeutic exposure suppressing immune networks below critical thresholds.
  • The CURE framework illustrates shared immunodynamic principles for managing various immune-mediated conditions.
  • Aligning therapeutic intensity with immune system dynamics enables personalized intervention.

Conclusions:

  • The CURE framework offers a transferable, mechanism-oriented approach for personalized chronic inflammation management.
  • It shifts disease management from reactive suppression to proactive, phase-specific immune stabilization.
  • This framework promotes functional remission, relapse prevention, and long-term tissue integrity across specialties.