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Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants
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It's what's on the inside that counts: Capsid content as a critical quality attribute for AAV characterization

Lauriel F Earley1, Stuart Nelson2, Ana Dolinar Češarek3

  • 1Earley Stage Gene Therapy Consulting, Tacoma, WA, USA.

Molecular Therapy. Advances
|June 30, 2026
PubMed
Summary

Recombinant adeno-associated virus (rAAV) vector characterization needs better methods to assess genome integrity. Current assays are insufficient, impacting gene therapy safety and efficacy.

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Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.