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Multiomics analyses in young grade C molar incisor pattern periodontitis
Meaad M Alamri1, Gordon Proctor2, Fernando Garcia-Guevara2
1Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom; Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Journal of Dentistry
|June 30, 2026
Summary
Young patients with severe periodontitis (C/MIP) exhibit a distinct dysbiotic microbiome and altered metabolic profile, with specific bacteria and metabolites potentially driving disease progression. This multi-omics study offers insights into C/MIP pathogenesis and identifies potential biomarkers.
Area of Science:
- Oral microbiology
- Metabolomics
- Periodontology
Background:
- Severe periodontitis in young patients (C/MIP) pathogenesis is complex.
- Understanding the interplay between microbial and metabolic profiles is crucial.
Purpose of the Study:
- To investigate microbial and metabolic profiles in young C/MIP patients.
- To compare these profiles with healthy controls.
- To integrate multi-omics data for elucidating C/MIP pathogenesis.
Main Methods:
- Shotgun sequencing metagenomics for bacterial profiles in saliva and plaque.
- Nuclear magnetic resonance and mass spectrometry for metabolic profiles in saliva and serum.
- Multi-omics data integration and network visualization.
Main Results:
- C/MIP patients showed distinct salivary and serum metabolite alterations.
- The plaque microbiome was enriched with pathogenic bacteria (e.g., D. oralis) and depleted of health-associated species.
- Specific metabolites (e.g., DL-glutamine, taurine) were associated with periodontal pathogens.
Conclusions:
- C/MIP is characterized by microbial dysbiosis and metabolic alterations.
- Key pathogens and metabolites contribute to disease progression.
- Multi-omics approach provides a foundation for understanding C/MIP and identifying biomarkers.
