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Updated: Jul 2, 2026

Detecting Pre-Stimulus Source-Level Effects on Object Perception with Magnetoencephalography
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Detecting Pre-Stimulus Source-Level Effects on Object Perception with Magnetoencephalography

Published on: July 26, 2019

Comparing aperiodic brain activity between eyes open rest and dynamic visual input using magnetoencephalography.

Tzu-Yu Hsu1, Ko-Ping Chou2, Yi-Ju Liu1

  • 1Institute of Cognitive Neuroscience, National Central University, Taoyuan, Taiwan.

Neuroimage
|June 30, 2026
PubMed
Summary
This summary is machine-generated.

Inscapes and eyes open rest yield different neural activity patterns, suggesting they are not interchangeable for brain imaging studies. This finding impacts analyses of excitation/inhibition balance and spectral dynamics.

Keywords:
Aperiodic activityExcitation/inhibition balanceInscapesMagnetoencephalographySpectral parameterisation

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Neural Oscillations

Background:

  • Inscapes is a low-demand animation used in neuroimaging as an alternative to eyes-open rest, especially for populations prone to head motion.
  • Prior research indicates functional connectivity during Inscapes resembles resting states.
  • Aperiodic neural activity, reflecting excitation-inhibition balance, has not been compared between these conditions.

Purpose of the Study:

  • To investigate differences in aperiodic neural activity between eyes open rest and Inscapes viewing.
  • To determine if Inscapes and eyes open rest are interchangeable for neuroimaging analyses of spectral dynamics.

Main Methods:

  • Magnetoencephalography (MEG) data were collected from 54 healthy adults.
  • Spectrally parameterized aperiodic and periodic measures were compared between eyes open rest and Inscapes viewing (visual component only).
  • Analyses were conducted at both sensor and source levels.

Main Results:

  • Eyes open rest showed significantly higher aperiodic exponent and offset compared to Inscapes across widespread brain regions.
  • These patterns were consistent across magnetometers and gradiometers at the sensor level.
  • Source-level analyses largely supported the sensor-level findings.

Conclusions:

  • Inscapes and eyes open rest result in distinct aperiodic spectral profiles.
  • The two conditions are not interchangeable for neuroimaging studies focusing on broadband spectral dynamics or excitation-inhibition balance.
  • Viewing dynamic visual stimuli (Inscapes) induces shifts in aperiodic activity in multiple brain regions compared to static rest.