Related Experiment Video

Updated: Jul 2, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Late-Onset Group B Streptococcus Sepsis Through the Lens of 28-Week-Old Triplets

Shenna Bannish1,2, Christina Hermos2,3, Nikita S Kalluri1,2

  • 1Department of Neonatology, University of Massachusetts Children's Medical Center, Worcester, Massachusetts.

Neoreviews
|June 30, 2026
PubMed

Insights

Late-onset Group B Streptococcus (GBS) disease poses diagnostic challenges in preterm infants, leading to severe complications and higher mortality. This case review highlights these risks in triplets born prematurely.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Pediatrics

Background:

  • Late-onset Group B Streptococcus (GBS) disease presents diverse clinical features, complicating diagnosis in preterm neonates.
  • Preterm infants face increased susceptibility and mortality risk from late-onset GBS disease compared to term infants.

Purpose of the Study:

  • To discuss the epidemiology, clinical presentation, and management of late-onset GBS disease.
  • To highlight the challenges in diagnosing and managing GBS in preterm infants using a case study of triplets.

Main Methods:

  • Case report of triplets born at 28 weeks' gestation with GBS complications.
  • Literature review on late-onset GBS disease epidemiology, clinical presentation, and management.

Main Results:

  • The case triplets exhibited multiple complications associated with late-onset GBS disease.
  • Preterm infants demonstrate a higher risk and mortality rate for GBS infections.

Conclusions:

  • Late-onset GBS disease requires vigilant diagnosis and management in preterm infants.
  • Understanding GBS epidemiology and clinical nuances is crucial for improving outcomes in vulnerable neonatal populations.

More Related Videos

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

Related Concept Videos

Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...