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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

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Breaking the Cycle: Comprehensive Strategies for Chronic Pain.

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Related Experiment Video

Updated: Jul 2, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
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A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

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Beyond Pills: Integrative Approaches to Pain Relief.

Melissa E Phuphanich1, Catherine Cho2, Andrew Lai2

  • 1Interventional Pain Service, Department of Physical Medicine and Rehabilitation, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard (W117), Los Angeles, CA 90073, USA; Division of Physical Medicine and Rehabilitation, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Physical Medicine and Rehabilitation Clinics of North America
|June 30, 2026
PubMed
Summary
This summary is machine-generated.

Integrative medicine offers an evidence-based alternative for chronic pain management, addressing limitations of drug-only strategies. These holistic approaches may reduce patient reliance on opioid medications.

Keywords:
Alternative medicineComplimentary medicineIntegrative medicineMovement therapy

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Development of Recombinant Proteins to Treat Chronic Pain

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Development of Recombinant Proteins to Treat Chronic Pain
10:37

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

Area of Science:

  • Integrative medicine
  • Pain management
  • Holistic health

Background:

  • Chronic pain impacts millions, leading to disability and increased healthcare costs.
  • Pharmacologic treatments for chronic pain have limitations and risks, including opioid dependence.
  • There is a growing need for effective, non-pharmacologic pain management strategies.

Purpose of the Study:

  • To review complementary, alternative, and integrative medicine (CAIM) modalities for chronic pain.
  • To highlight evidence-based CAIM approaches for patient-centered care.
  • To explore how CAIM can reduce reliance on opioid medications.

Main Methods:

  • Literature review of CAIM modalities for chronic pain.
  • Categorization of therapies including manual, movement-based, and electrotherapies.
  • Synthesis of evidence supporting CAIM in pain management.

Main Results:

  • Manual therapies (e.g., chiropractic, massage) show promise in pain relief.
  • Movement-based therapies (e.g., yoga, tai chi) improve function and reduce pain.
  • Acupuncture, TENS, and scrambler therapy are effective adjuncts in pain management.

Conclusions:

  • Integrative medicine provides a holistic, patient-centered approach to chronic pain.
  • CAIM modalities can complement conventional treatments and potentially reduce opioid use.
  • Evidence supports the use of various CAIM therapies for managing chronic pain effectively.