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Published on: February 1, 2020
Impact of Cirrhosis Outcome Risk Estimator Score on Outcomes Following Pancreatectomy for Resectable Pancreatic
Kazuya Yasui1, Kosei Takagi2, Tomokazu Fuji1
1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Background/Aim:
The Cirrhosis Outcome Risk Estimator (CORE) score is a novel model designed to predict the risk of liver disease. However, data regarding the prognostic utility of the CORE score in patients with resectable pancreatic ductal adenocarcinoma (R-PDAC) remain scarce. This study aimed to evaluate the utility of the CORE score as a prognostic stratification tool for R-PDAC.
Patients And Methods:
We retrospectively analyzed 242 patients who underwent pancreatectomy for R-PDAC between January 2009 and December 2023. Patients were stratified into two groups based on their preoperative CORE scores. Multivariate analyses were performed to identify independent predictors of recurrence-free survival (RFS) and overall survival (OS), comparing perioperative outcomes between the groups.
Results:
Of the 242 patients, 73 (30.2%) were classified into the high CORE score group (score >0.9). Patients in the high CORE score group exhibited significantly worse five-year RFS (18.0% vs. 40.1%, p=0.001) and OS (25.9% vs. 51.0%, p=0.001) than those in the low CORE score group. Multivariate analyses identified a low CORE score as an independent predictor of RFS [hazard ratio (HR)=1.53, p=0.014] and OS (HR=1.70, p=0.004).
Conclusion:
The CORE score is a robust, simple preoperative predictor of survival following pancreatectomy for R-PDAC.
