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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

Updated: Jul 2, 2026

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
09:58

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

Published on: November 9, 2018

18F-fluorodeoxyglucose PET in Major Psychiatric Disorders.

Rodolfo Ferrando1, Artur Martins Coutinho2

  • 1Academic Unit of Nuclear Medicine and Molecular Imaging, Hospital de Clínicas, Universidad de la República (UDELAR); Department of Functional Brain Imaging, Uruguayan Center for Molecular Imaging (CUDIM), Montevideo, Uruguay.

PET Clinics
|June 30, 2026
PubMed
Summary
This summary is machine-generated.

18F-fluorodeoxyglucose (FDG)-PET imaging reveals brain network abnormalities in psychiatric disorders like schizophrenia and mood disorders. While not diagnostic, FDG-PET aids in complex cases by supporting phenotyping and differential diagnosis.

Keywords:
Bipolar disorderDepressive disorderDiagnosisDifferentialFluorodeoxyglucose F18Positron-emission tomographySchizophreniaSubstance-related disorders

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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

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Last Updated: Jul 2, 2026

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Published on: November 9, 2018

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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Systems Neuroscience

Background:

  • 18F-fluorodeoxyglucose (FDG)-PET provides a systems-level perspective on brain dysfunction in psychiatric conditions.
  • Findings are more informative at the circuit and network level rather than as fixed disease patterns.

Purpose of the Study:

  • To review principal FDG-PET findings in major psychiatric disorders.
  • To integrate FDG-PET data with molecular imaging findings.
  • To highlight the utility of FDG-PET in complex diagnostic scenarios.

Main Methods:

  • Systematic review of FDG-PET studies in psychiatry.
  • Integration of findings across schizophrenia, addictions, and mood disorders.
  • Consideration of clinical state, stage, treatment, and comorbidity effects.

Main Results:

  • Reproducible abnormalities identified in prefrontal, limbic, striatal, and associative networks across disorders.
  • Abnormalities vary based on clinical factors.
  • FDG-PET findings support phenotyping and differential diagnosis in complex cases.

Conclusions:

  • FDG-PET offers valuable insights into brain network dysfunction in psychiatric disorders.
  • It is a useful adjunct tool for complex cases, aiding in differentiation from other brain disorders.
  • FDG-PET is not a standalone diagnostic test for primary psychiatric disorders.