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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
Published on: April 30, 2021
Integrating artificial intelligence into small molecule development for precision cancer immunomodulation therapy
Henry Sutanto1,2, Deasy Fetarayani3,4
1Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Abstract:
This perspective examines how artificial intelligence (AI) is transforming small-molecule development for precision cancer immunomodulation therapy. It outlines AI-driven approaches for de novo design, virtual screening, multi-parameter optimization, and ADMET prediction, targeting immune checkpoints, tumor microenvironment modulation, antigen presentation, and metabolic pathways. The article highlights patient stratification, multi-omics integration, digital twin simulations, translational challenges, and future directions, underscoring AI's potential to deliver effective, personalized immunomodulatory therapeutics.
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