Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Influence of sampling satisfaction using endometrial sampling device and related factors for pathology diagnostic accordance rate].

Zhonghua fu chan ke za zhi·2014
Same author

Effect of the number of positive lymph nodes and lymph node ratio on prognosis of patients after resection of pancreatic adenocarcinoma.

Hepatobiliary & pancreatic diseases international : HBPD INT·2014
Same author

Mechanisms of human erythrocytic bioactivation of nitrite.

The Journal of biological chemistry·2014
Same author

Simulation research on the natural degradation process of PBDEs in soil polluted by e-waste under increased concentrations of atmospheric O(3).

Chemosphere·2014
Same author

Two-dimensional colloidal crystal assisted formation of conductive porous gold films with flexible structural controllability.

Journal of colloid and interface science·2014
Same author

REDD1 attenuates cardiac hypertrophy via enhancing autophagy.

Biochemical and biophysical research communications·2014

Related Experiment Videos

Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.

Yunyao Yang1,2, Jiayong Li1,2, Xixi Xiao1,2

  • 1Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Comprehensive Physiology
|July 1, 2026
PubMed
Summary

Different obesity measures link to heart failure (HF) through distinct biological pathways. Understanding these mechanisms can personalize risk assessment and interventions for obese patients.

Keywords:
anthropometric indicesbiological processheart failureobesityproteomics

Related Experiment Videos

Area of Science:

  • Cardiology
  • Proteomics
  • Obesity research

Background:

  • Obesity is a significant risk factor for heart failure (HF).
  • The specific biological pathways connecting various obesity indices to HF remain largely undefined.
  • Novel adiposity indices require investigation to elucidate their mechanistic links to HF.

Purpose of the Study:

  • To identify proteomic mediators for five novel obesity indices: waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHTR), body roundness index (BRI), and weight-adjusted waist index (WWI).
  • To elucidate the distinct mechanistic pathways linking these adiposity indices to heart failure.
  • To translate these mechanistic differences into clinical practice for improved patient management.

Main Methods:

  • Utilized UK Biobank data for comprehensive analysis.
  • Employed Cox and linear regression to identify proteins associated with both HF and each obesity index.
  • Conducted mediation and Gene Ontology (GO) enrichment analyses to understand pathway involvement.

Main Results:

  • All five assessed obesity indices demonstrated a significant association with HF risk.
  • Waist-to-hip ratio (WHR) and waist-to-height ratio (WHTR) exhibited the strongest associations with HF.
  • Distinct proteomic pathways were identified for each index, reflecting a pathological continuum from early adipose dysfunction (BRI) to established organ damage (WWI, WC), with intermediate roles for WHR and WHTR.

Conclusions:

  • Each obesity index occupies a unique position in the progression of heart failure, offering specific mechanistic insights.
  • These findings enable more individualized risk assessment for obese patients.
  • Mechanism-based interventions can be developed for obese patients based on these distinct pathway discoveries.