Related Experiment Video
Updated: Jul 2, 2026

Localization, Identification, and Excision of Murine Adipose Depots
Published on: December 4, 2014
The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure
1Helix Research Lab, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India.
None:
The diagnostic landscape of obesity is transitioning from weight centric metrics toward a functional "clinical obesity" framework. This review explores the pathophysiology of adiposopathy ("sick fat"), where hypertrophic adipose tissue triggers systemic metabolic failure via the adipose-hepatic axis. Impaired subcutaneous adipose tissue (SAT) expandability, ectopic lipid accumulation, chronic inflammation, and maladaptive endocrine signaling are the hallmarks of adiposopathy ("sick fat"), a worldwide adipose tissue dysfunction. Through integrated adipose-organ communication networks, these changes support systemic cardiometabolic illness, MASLD, and hepatic insulin resistance. The molecular roles of DJ-1, Nrf2, and inflammatory kinases (JNK/IKKβ) in mediating this metabolic hit were examined in this study.
Related Concept Videos
Obesity
Hypodermis
Type II Diabetes II: Pathophysiology
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Loose Connective Tissue
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
Type I Diabetes III: Clinical Manifestations
